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Helpful tips for getting started on Adalimumab-adbm

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If you were switched from Humira® to Adalimumab-adbm due to insurance coverage, talk to your doctor about any questions you have about biosimilars
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Because Adalimumab-adbm is a specialty medication, it may require additional approval from your insurance company and is typically shipped from a specialty pharmacy. This process could take a few days
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Once your prescription is approved, a specialty 
pharmacy will contact you to schedule shipments of Adalimumab-adbm. You may not recognize the phone number, but be sure to answer these calls and save the pharmacy’s number. You won’t be able to receive Adalimumab-adbm until you speak to someone from the specialty pharmacy
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TIP! Save the toll-free phone number of the specialty pharmacy in your phone for future calls
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Once you know when you will be receiving 
Adalimumab-adbm, speak to your doctor to confirm your dosing schedule. Your doctor or someone from the care team will show you how to use Adalimumab-adbm
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If needed, schedule additional injection education with your doctor
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While insurance will ultimately determine which product you will receive, Adalimumab-adbm and CYLTEZO® are the exact same medicine
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Take control of your treatment journey by learning how to confidently inject Adalimumab-adbm

For most patients, Adalimumab-adbm is injected at home under the skin using either a pen or a prefilled syringe

  • Your doctor may prescribe a dose that requires you to use more than one pen or prefilled syringe

  • It is important to talk to your doctor to be sure you understand your dosing instructions. They will tell you how often you need to inject Adalimumab-adbm and make sure you’re able to inject it yourself

  • Speak to your doctor before starting injections on your own to ensure that you have the proper injection training, and read the Instructions for Use

Here are some tips to keep in mind for your Adalimumab-adbm injection:

  • Consider finding a quiet, calm space for your injection

  • Gather your supplies: pen or prefilled syringe, FDA-cleared sharps disposal container, cotton balls, alcohol wipes, and Instructions for Use

  • Wash your hands with soap and water and dry them well

  • If using the pen, pull the cap straight off. DO NOT twist the cap

  • Select an injection site on the upper thighs or the stomach

  • Mark injection dates on your calendar

Videos and downloads

Videos

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Watch and learn how to inject with the Adalimumab-adbm pen

This video demonstrates how to inject Adalimumab-adbm using the pen.Please read the complete Instructions for Use contained in your Adalimumab-adbm package.
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Downloads

Injection tracker brochure

Injection tracker

Use this tracker to stay on top of your schedule and record any symptoms you may experience to share with your doctor.
What is Adalimumab-adbm?

Adalimumab-adbm is a medicine called a tumor necrosis factor (TNF) blocker. Adalimumab-adbm is used:

  • To reduce the signs and symptoms of:
    • moderate to severe rheumatoid arthritis (RA) in adults. Adalimumab-adbm can be used alone, with methotrexate, or with certain other medicines.
    • moderate to severe polyarticular juvenile idiopathic arthritis (JIA) in children 2 years and older. Adalimumab-adbm can be used alone or with methotrexate.
    • psoriatic arthritis (PsA) in adults. Adalimumab-adbm can be used alone or with certain other medicines.
    • ankylosing spondylitis (AS) in adults.
    • moderate to severe hidradenitis suppurativa (HS) in people 12 years and older.
  • To treat moderate to severe Crohn’s disease (CD) in adults and children 6 years of age and older.
  • To treat moderate to severe ulcerative colitis (UC) in adults. It is not known if adalimumab products are effective in people who stopped responding to or could not tolerate TNF-blocker medicines.
  • To treat moderate to severe chronic (lasting a long time) plaque psoriasis (Ps) in adults who have the condition in many areas of their body and who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills).
  • To treat non-infectious intermediate, posterior, and panuveitis in adults and children 2 years of age and older.
Important Safety Information for Adalimumab-adbm (adalimumab-adbm) injection, for subcutaneous use

This important information also applies to CYLTEZO® (adalimumab-adbm) injection for subcutaneous use. 

What is the most important information I should know about Adalimumab-adbm?

You should discuss the potential benefits and risks of Adalimumab-adbm with your doctor. Adalimumab-adbm is a TNF-blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking Adalimumab-adbm if you have any kind of infection unless your doctor says it is okay.

  • Serious infections have happened in people taking adalimumab products. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting Adalimumab-adbm and check you closely for signs and symptoms of TB during treatment with Adalimumab-adbm, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
  • Cancer. For children and adults taking TNF blockers, including Adalimumab-adbm, the chances of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers, including Adalimumab-adbm, your chances of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.

What should I tell my doctor BEFORE starting Adalimumab-adbm?

Tell your doctor about all of your health conditions, including if you:

  • Have an infection, are being treated for infection, or have symptoms of an infection.
  • Get a lot of infections or have infections that keep coming back.
  • Have diabetes.
  • Have TB or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB.
  • Live or have lived in an area (such as the Ohio and Mississippi River valleys) where there is an increased risk for getting certain kinds of fungal infections, such as histoplasmosis, coccidioidomycosis, or blastomycosis. These infections may happen or become more severe if you use Adalimumab-adbm. Ask your doctor if you are unsure whether you have lived in an area where these infections are common.
  • Have or have had hepatitis B.
  • Are scheduled for major surgery.
  • Have or have had cancer.
  • Have numbness or tingling or a nervous system disease such as multiple sclerosis or Guillain-Barré syndrome.
  • Have or had heart failure.
  • Have recently received or are scheduled to receive a vaccine. Adalimumab-adbm patients may receive vaccines, except for live vaccines. Children should be brought up to date on all vaccines before starting Adalimumab-adbm.
  • Are allergic to rubber or latex.
  • Are allergic to any Adalimumab-adbm ingredients.
  • Are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.
  • Have a baby and you were using Adalimumab-adbm during your pregnancy. Tell your baby’s doctor before your baby receives any vaccines.

Also tell your doctor about all the medicines you take. You should not take Adalimumab-adbm with ORENCIA® (abatacept), KINERET® (anakinra), REMICADE® (infliximab), ENBREL® (etanercept), CIMZIA® (certolizumab pegol), or SIMPONI® (golimumab). Tell your doctor if you have ever used RITUXAN® (rituximab), IMURAN® 
(azathioprine), or PURINETHOL® (mercaptopurine, 6-MP).

What should I watch for AFTER starting Adalimumab-adbm?

Adalimumab-adbm can cause serious side effects, including:

  • Serious infections. These include TB and infections caused by viruses, fungi, or bacteria. Symptoms related to TB include a cough, low-grade fever, weight loss, 
    or loss of body fat and muscle.
  • Hepatitis B infection in carriers of the virus. Symptoms include muscle aches, feeling very tired, dark urine, skin or eyes that look yellow, little or no appetite, 
    vomiting, clay-colored bowel movements, fever, chills, stomach discomfort, and skin rash.
  • Allergic reactions. Symptoms of a serious allergic reaction include hives; trouble breathing; and swelling of your face, eyes, lips, or mouth.
  • Nervous system problems. Signs and symptoms include numbness or tingling, problems with your vision, weakness in your arms or legs, and dizziness.
  • Blood problems (decreased blood cells that help fight infections or stop bleeding). Symptoms include a fever that does not go away, bruising or bleeding very 
    easily, or looking very pale.
  • Heart failure (new or worsening). Symptoms include shortness of breath, swelling of your ankles or feet, and sudden weight gain.
  • Immune reactions, including a lupus-like syndrome. Symptoms include chest discomfort or pain that does not go away, shortness of breath, joint pain, or rash on your cheeks or arms that gets worse in the sun.
  • Liver problems. Symptoms include feeling very tired, skin or eyes that look yellow, poor appetite or vomiting, and pain on the right side of your stomach 
    (abdomen). These problems can lead to liver failure and death.
  • Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

Call your doctor or get medical care right away if you develop any of the above symptoms.

The most common side effects of Adalimumab-adbm include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all the possible side effects with Adalimumab-adbm. Tell your doctor if you have any side effect that bothers you or that does not go away.

Remember to tell your doctor right away if you have an infection or symptoms of an infection, including:

  • Fever, sweats, or chills
  • Muscle aches
  • Cough
  • Shortness of breath
  • Blood in phlegm
  • Weight loss
  • Warm, red, or painful skin or sores on your body
  • Diarrhea or stomach pain
  • Burning when you urinate
  • Urinating more often than normal
  • Feeling very tired

These are not all the possible side effects of Adalimumab-adbm. For more information, speak with your doctor or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

CL-AA-100003 OCT 2025

Please see the Medication Guide and Instructions for Use for Adalimumab-adbm. Please see the Medication Guide and Instructions for Use for CYLTEZO.